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Post by brussie on Jul 28, 2011 18:45:22 GMT -5
So this is definitely not an accepted standard of care yet, but this study suggests that treatment with quinagolide (a dopamine agonist) can significantly decrease number and size of endometriotic lesions: www.medbioworld.com/news.php?topic=0&article=20101119clin008.xmlIt works because it is an angiogenesis inhibitor (and a couple other mechanisms are also theorized). I think it's exciting because it does not affect fertility (ie. not contra-indicated for women looking to become pregnant) and because the side effects don't look horrible (nausea mostly). I wonder if other dopamine agonists such as cabergoline and bromocriptine would also work. I know these are sometimes prescribed for women with severe cyclic breast pain. I actually discussed that with my doctor awhile back (before I knew of the endometriosis implications of dopamine agonists). Does anyone have any experience with dopmaine agonists?
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Post by Karen on Jul 28, 2011 20:24:45 GMT -5
Haven't heard of it yet, but sounds quite interesting! It's nice to know that people are looking at other options other than just those that kill estrogen levels and mess with our cycles...
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Post by JC on Jul 29, 2011 8:28:14 GMT -5
Hey! This is one of the drugs that treats prolactinomas!
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Post by 1234 on Jul 29, 2011 8:37:23 GMT -5
I'm having difficulty following the vocabulary in this post, but would this sort of treatment help folks with low neurotransmitter levels more?
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Post by JC on Jul 29, 2011 10:10:52 GMT -5
The drug acts as a dopamine agonist. Apparently the research being presented here says it can help with endometriosis implants because it inhibits angiogenesis. Angiogenesis is when abnormal cells grown their own vascular network. If you cut off that vasculature then the abnormal cells won't get nutrients and won't survive.
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Post by omaklackey on Jul 29, 2011 20:22:50 GMT -5
thank Jenaya, I understood your description a little better. I studied this stuff and I was still pretty lost! It would be awesome to have a new kind of treatment.
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Post by brussie on Jul 29, 2011 22:26:03 GMT -5
Yeah, anything that could treat endometriosis without messing up my hormones and, at the same time, remedy my horrible cyclic breast pain sounds kind of amazing! Here's a link to the PubMed abstract if folks want more info: www.ncbi.nlm.nih.gov/pubmed/21055747?dopt=Abstract
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