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Post by amber84 on Sept 15, 2010 0:21:28 GMT -5
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Post by Heather on Oct 13, 2010 1:46:43 GMT -5
I wonder how much progress they have made in the past year. I'm only about 3 hours from Boston, I wonder if they could use me as a test subject.
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Post by Karen on Oct 13, 2010 6:14:46 GMT -5
I'm just glad the news is getting out that more people are researching! Wouldn't it be great if, in 10 years, much more effective and less harsh treatments are available?
A while back, Jenaya sent me an article summarizing the latest treatment methods that are being researched - some of them sound really, really promising! Doesn't hurt to see if any of them are looking for study participants (though be sure to research it thoroughly!).
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Post by gemstone on Oct 13, 2010 12:13:42 GMT -5
Does anyone know of any good articles on Polycystic Ovaries. My friend has been trying to conceive and her doc now suspects this. She's then googled it and freaked out. I don't know much about it so thought I'd ask the Encyclopedia of Lady Bits if they had any wisdom
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Post by hellsbells on Oct 13, 2010 14:13:02 GMT -5
I've googled it loads...there's a glut of info on it.
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Post by JC on Oct 16, 2010 8:04:09 GMT -5
Treating endometriosis as an autoimmune disease
Warren B. Nothnick Ph.D., , a
a Departments of Obstetrics and Gynecology and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA
Received 13 December 2000; revised 16 February 2001; accepted 16 February 2001 Available online 23 July 2001.
Abstract Objective: To review the literature on the role of autoimmunity in the etiology of endometriosis, compare the similarities in the pathophysiologies between endometriosis and autoimmune diseases, and discuss the use of immunomodulators currently used to treat autoimmune diseases as potential therapies for endometriosis.
Design: The literature on endometriosis and other autoimmune diseases was reviewed, and summary data are presented.
Results: Endometriosis shares many similarities with autoimmune diseases such as rheumatoid arthritis, Crohn’s disease, and psoriasis. These similarities include elevated levels of cytokines, decreased cell apoptosis, and T- and B-cell abnormalities. Because the use of immunomodulators and inflammatory modulators has proven to be an effective means of medical management for these autoimmune diseases, similar therapies may prove useful in treating endometriosis.
Conclusion(s): Although substantial evidence indicates that endometriosis at least shares many similarities with autoimmune diseases, endometriosis is primarily treated by using compounds that induce a hypoestrogenic environment. A review of the literature combined with the shortcomings of current means of medical management for endometriosis support the postulate that treatment of endometriosis with immunomodulators and inflammatory modulators is warranted.
Attention: This is just a summary of research. If you want the entire study please send me a personal message and I can download the entire study and email it to you.
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Post by JC on Oct 16, 2010 8:05:03 GMT -5
"Is endometriosis an endometrial disease? " D. Vinatier MD, , M. Cosson MD and P. Dufour MD
Hôpital Jeanne de Flandre, Clinique de Gynécologie et d’Obstétrique, Centre Hospitalier Universitaire de Lille, F59037 Lille Cedex, France
Received 4 August 1999; accepted 10 September 1999. Available online 22 June 2000.
Abstract Endometriosis is characterised by the presence of abnormally located tissue resembling the endometrium with glands and stroma. Several hypotheses have attempted to explain the development of such tissue. The most often cited theory, that of implantation, proposes that the physiological phenomenon of endometrial reflux in the fallopian tubes during menstruation may, in certain conditions, overcome local defense mechanisms, implant, and proliferate. The implantation theory does not explain why endometriosis will develop only in 10–15% of women, while the reflux of endometrial tissue via the fallopian tubes during menstruation is a quasi-universal phenomenon. The endometrium of women affected by endometriosis could be abnormal compared with endometrium of healthy women. The abnormal endometrium could be able to protect itself from harmful effects of immune cells by expressing specific antigens, by harbouring a different immune cell population and by synthetizing and secreting immunosuppressive factors. Several others characteristic features of endometrium have been described in women with endometriosis: (1) production of its own estrogens in too heavy amount; (2) aptitude for setting up on peritoneum; (3) tendencies to proliferate and to invade tissue; (4) aggressiveness for the peritoneum; (5) auto-protection from physiological apoptosis; (6) abnormal expression of heat shock proteins; and (7) excessive angiogenesis.
Attention: This is just a summary of research. If you want the entire study please send me a personal message and I can download the entire study and email it to you.
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Post by JC on Oct 16, 2010 8:05:47 GMT -5
Development of a nonsurgical diagnostic tool for endometriosis based on the detection of endometrial leukocyte subsets and serum CA-125 levels*1
Presented at the VIII World Congress on Endometriosis organized by the American Society for Reproductive Medicine, San Diego, California, February 24–27, 2002. Danièle Gagné M.Sc.a, Michèle Rivard Sc.D.b, Martin Pagé B.Sc.a, Manon Lépine M.Sc.a, Christèle Platon M.Sc.a, Kamran Shazand Ph.D.a, Patrice Hugo Ph.D.a and Diane Gosselin Ph.D., , a
a MetrioGene, Montréal, Québec, Canada
b University of Montréal, Departement de Médecine Sociale et Préventive, Montréal, Québec, Canada
Received 21 January 2003; revised 30 April 2003; accepted 30 April 2003. ; Available online 3 October 2003.
Abstract Objective To determine whether the proportion of several leukocyte subsets is modulated in the endometrium of patients with endometriosis and, if yes, whether it can be used for diagnostic purposes.
Design: Case-control study.
Setting: Eight clinical institutions of the Montreal area.
Patient(s): Women who underwent laparoscopy or laparotomy between 1997 and 2001, who had regular menstrual cycles and were not under hormone treatment for the previous 3 months were selected. This study included 368 women, 173 with surgically confirmed endometriosis and 195 controls with no surgical evidence of endometriosis.
Intervention(s): Main outcome measure(s): Cytometry analysis was used to measure the proportion of several leukocyte subsets among CD45+ endometrial cells.
Result(s): The proportion of CD3+, CD16+, CD3−HLADR−, CD3-CD45RA−, CD3+CD16−, CD3+CD56−, CD56−CD16+, and CD16b+ leukocytes was significantly altered in the endometrium of cases compared with controls. A multiple logistic regression model was adjusted with these endometrial leukocytes, serum CA-125 levels, risk factors, and confounders. The diagnostic performance of this predictive model was defined by a specificity of 95% and a sensitivity of 61%. Furthermore, the positive and negative predictive values were 91% and 75%, respectively.
Conclusion(s) This predictive model represents a novel diagnostic tool to identify women with a high likelihood of suffering from endometriosis.
Attention: This is just a summary of research. If you want the entire study please send me a personal message and I can download the entire study and email it to you.
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Post by Karen on Oct 16, 2010 8:23:08 GMT -5
Oooh, thanks! I've been a big believer of the endo link to the immune system. It can't just be hormones!!
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Post by JC on Oct 16, 2010 11:06:42 GMT -5
I like the idea of a non-surgical way to diagnose this crap. Although, it is nice to have things biopsied and looked at for peace of mind too... hmm pros and cons!
There's SO MANY good articles in the reasearch data base. I'm going to dig up as many as I can to post here. They're amazing. I wish our doctors would read these things!
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Post by hellsbells on Oct 23, 2010 11:35:25 GMT -5
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Post by JC on Oct 23, 2010 17:35:35 GMT -5
Wow what a great description that gave!
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Post by Tamela on Oct 23, 2010 19:46:21 GMT -5
That is a great brochure. I sent it to my Mom and sister who often don't understand what Endo is. thanks for sharing it. I was so surprised to see that only 15% of women with Endo have ovarian cysts. That doesn't seem right to me.
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Post by hellsbells on Oct 24, 2010 4:07:56 GMT -5
I'm surprised it says so few women have endo of the urinary tract, so many of us seem to have it!
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Post by JC on Oct 28, 2010 8:10:37 GMT -5
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