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Post by loveshoes on Feb 29, 2012 18:48:37 GMT -5
I got this from the endo association and I was wondering if anyone knows if the ovarian cancer risk is increased only if you have endo found on your ovaries? Ovarian cancer is harder to detect - does anyone know how we can protect ourselves against this? Seems like ovarian cancer symptoms are pretty identical to endo symptoms so how would you know when something might be wrong? Are there specific tests to have completed to find ovarian cancer other than the manual check by the Gyno?
Dear Endo Friend, There has been an avalanche of response to Endometriosis Awareness Month this year – thanks to everyone who is helping to reach out to educate and assist families affected by this miserable disease. And now, after last week’s scientific report on the increased risk for three ovarian cancers (a deadly cancer) in women with a history of endo (even going back many years), we know more than ever that we must reach those with endometriosis to help. Indeed, lives can be saved if women and girls have their pain and symptoms taken seriously, get diagnosed, and become proactive in taking charge of their health. In fact, the Endometriosis Association has led the way with its groundbreaking research over the years showing the higher risk of a number of cancers for those of us with a history of endometriosis.
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Post by rhodygirl on Mar 24, 2012 13:52:54 GMT -5
mthfr.net/endometriosis-mthfr/2012/03/24/"Endometriosis and the Genetic Defect Connection In order to process xenoestrogens, one must have functional detoxification pathways. There are countless genes whose function is to detoxify substances and eliminate them from the body. A few of these genes are known as MTHFR, COMT, SOD1, SOD2, GSTM1 and various CYT. If these genes are mutated or deleted, then the elimination of xenoestrogens is limited at best. The MTHFR gene mutation, especially the C677T form, may cause a deficiency in the production of the body’s largest single carbon donor, SAMe. SAMe is extremely important in detoxification . MTHFR C677T individuals are limited in their ability to produce glutathione, which is a significant contributor to detoxification."
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Post by Karen on Mar 29, 2012 22:28:59 GMT -5
Here's an article on the market of endo-related treatments: www.prweb.com/releases/endometriosis/laproscopy_infertility/prweb9346037.htm Sad but true - money will drive the research and development of new therapies for endo. Perhaps the awareness of how much of a market there is for endo will give researchers a kick in the pants to come up with something new? It's quite depressing to have our lives summarized by a dollar figure, though.
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Post by JC on Apr 24, 2012 6:32:15 GMT -5
I ran across this book today. This author Jerome Groopman writes tons of medical articles for the New Yorker. This book looks interesting. "How Doctors Think is a window into the mind of a physician and an insightful examination of the all-important relationship between doctors and their patients. In this myth-scattering work, Jerome Groopman explores the forces and thought processes behind the decisions doctors make. He pinpoints why doctors succeed and why they err. Most important, Groopman shows when and how doctors can - with our help - avoid snap judgements, embrace uncertainty, communicate effectively, and deploy other skills that can profoundly impact our health." www.jeromegroopman.com/how-doctors-think.htmlHere is a link to all of his medical articles that he has written for the New Yorker. jeromegroopman.com/articles.html
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Wendy
Junior Member
Posts: 74
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Post by Wendy on Oct 11, 2012 2:03:51 GMT -5
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Post by liliegazer on Oct 11, 2012 23:19:05 GMT -5
This was an absolutely beautiful article, Wendy! Thanks for sharing!
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Wendy
Junior Member
Posts: 74
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Post by Wendy on Oct 13, 2012 21:15:47 GMT -5
Very welcome.
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Post by JC on Oct 21, 2012 13:55:19 GMT -5
I attached an incredible article. It's pretty scientifically dense but what these researchers examined was how endometrial cells outside of the uterus are different from endometrial cells inside the uterus. They found that the abnormal endometrial cells outside of the body are resistant to the body's normal process of cell death which happens once a month to shed the lining of the uterus to have a period. This is what they believe contributes to how difficult it is to treat endometriosis. Many of our medications work really well on normal endometrial tissue, but normal tissue isn't our problem. It's when the tissue becomes abnormal and grows outside of the uterus. I think what researchers need to do is find exactly how these cells differ from normal cells and then target those differences with drug treatment. We get treated with birth control under the assumption that the endometrial cells outside of the uterus are exactly the same as the normal cells. That's just not true. Drug treatment should be more specific than that. It will be years before we ever reach that point but it would be nice if more research was done to examine these differences. This particular study was done in Japan. Attachments:
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Post by 1234 on Oct 21, 2012 18:07:09 GMT -5
I can't access this for some reason, but it is something I am really interested in. I've also read that the uterine lining of some women with really severe endo is also altered--includes more nerve endings and also secretes its own inflammatory proteins or something. Which is fascinating to me.
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Post by semicolon on Oct 21, 2012 18:57:36 GMT -5
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Post by liliegazer on Oct 22, 2012 16:44:05 GMT -5
Thanks for posting! So interesting I had to dig a little to understand a little more about survivin...found it here...although do take it with a grain of salt, as it is wikipedia. en.wikipedia.org/wiki/SurvivinThe article Semi posted stated the following... "We demonstrated that survivin plays a critical role in susceptibility of ESCs to apoptosis. Our results indicate that a survivin inhibitor may be effective as a novel treatment for endometriosis." It made me wonder if there are any natural survivin inhibitor treatments that have been studied or if one even exists?
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Post by 1234 on Oct 22, 2012 19:00:14 GMT -5
Thanks, Semi!
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Post by JC on Oct 22, 2012 19:09:01 GMT -5
Thanks for posting! So interesting I had to dig a little to understand a little more about survivin...found it here...although do take it with a grain of salt, as it is wikipedia. en.wikipedia.org/wiki/SurvivinThe article Semi posted stated the following... "We demonstrated that survivin plays a critical role in susceptibility of ESCs to apoptosis. Our results indicate that a survivin inhibitor may be effective as a novel treatment for endometriosis." It made me wonder if there are any natural survivin inhibitor treatments that have been studied or if one even exists? It probably hasn't been studied. One thing you always have to keep in mind in these studies is that it's easy to want a drug that targets this specific pathway in the development of endometriosis. What you have to take into consideration is whether or not this "survivin" has a role somewhere else in the body. If you inhibit this protein then will it effect some other vital process somewhere else? I think developing a drug for this is a lonnnnng way away but it at least paints a possible new direction for research. Maybe it will give researchers an idea on how to identify abnormal vs. normal endometrial cells so that they can make treatment more specific. Oh sigh. A girl can only dream...
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Post by liliegazer on Feb 22, 2013 12:19:54 GMT -5
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Wendy
Junior Member
Posts: 74
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Post by Wendy on Mar 2, 2013 16:18:53 GMT -5
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